Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome

In patients with the metabolic syndrome (MetS), the facilitatory effect of insulin on forearm vasodilator responsiveness to different stimuli is impaired. Whether the RhoA/Rho kinase (ROCK) pathway is involved in this abnormality is unknown. We tested the hypotheses that, in MetS patients, ROCK inhi...

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Detalhes bibliográficos
Main Authors: Schinzari, Francesca, Tesauro, Manfredi, Rovella, Valentina, Di Daniele, Nicola, Gentileschi, Paolo, Mores, Nadia, Campia, Umberto, Cardillo, Carmine
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468433/
https://ncbi.nlm.nih.gov/pubmed/22829585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00206.2012
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