Toll-Like Receptor 4 Mediates Endothelial Cell Activation Through NF-κB but Is Not Associated with Endothelial Dysfunction in Patients with Rheumatoid Arthritis

OBJECTIVE: To investigate the effects of TLR4 antagonism on human endothelial cells activation and cytokine expression, and whether the Asp299Gly TLR4 polymorphism is associated with better endothelial function in patients with rheumatoid arthritis (RA). METHODS: Human aortic endothelial cells (HAEC...

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Autores principales: Menghini, Rossella, Campia, Umberto, Tesauro, Manfredi, Marino, Arianna, Rovella, Valentina, Rodia, Giuseppe, Schinzari, Francesca, Tolusso, Barbara, di Daniele, Nicola, Federici, Massimo, Zoli, Angelo, Ferraccioli, Gianfranco, Cardillo, Carmine
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053330/
https://ncbi.nlm.nih.gov/pubmed/24918924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099053
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