Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome

In patients with the metabolic syndrome (MetS), the facilitatory effect of insulin on forearm vasodilator responsiveness to different stimuli is impaired. Whether the RhoA/Rho kinase (ROCK) pathway is involved in this abnormality is unknown. We tested the hypotheses that, in MetS patients, ROCK inhi...

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Hlavní autoři: Schinzari, Francesca, Tesauro, Manfredi, Rovella, Valentina, Di Daniele, Nicola, Gentileschi, Paolo, Mores, Nadia, Campia, Umberto, Cardillo, Carmine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468433/
https://ncbi.nlm.nih.gov/pubmed/22829585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00206.2012
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