Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule

To elucidate the role of the insulin receptor (IR) on kidney nitric oxide generation and blood pressure (BP) control, we generated mice with targeted deletion of renal tubule IR using loxP recombination driven by a Ksp-cadherin promoter. Male knockout (KO) and wild-type (WT) littermates (∼4 mo old)...

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Detalhes bibliográficos
Main Authors: Li, Lijun, Garikepati, R. Mayuri, Tsukerman, Susanna, Tiwari, S., Ecelbarger, Carolyn M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Fluid and Electrolyte Homeostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468417/
https://ncbi.nlm.nih.gov/pubmed/22814664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00033.2012
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