Generation of a Novel, Cox2-Targeted, Interferon-Expressing, Conditionally-Replicative Adenovirus for Pancreatic Cancer Therapy

BACKGROUND: Oncolytic adenoviruses provide a promising alternative for cancer treatment. Recently, adjuvant α-interferon has shown significant survival benefits for pancreatic cancer, yet was impeded by systemic toxicity. To circumvent these problems adenovirus with high-level targeted IFNα expressi...

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Bibliographische Detailangaben
Hauptverfasser: Armstrong, Leonard, Arrington, Amanda, Han, Joohee, Gavrikova, Tatyana, Brown, Eric, Yamamoto, Masato, Vickers, Selwyn M., Davydova, Julia
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467355/
https://ncbi.nlm.nih.gov/pubmed/22748294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.amjsurg.2012.02.016
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