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Subtle changes in TCRα CDR1 profoundly increase the sensitivity of CD4 T cells
Changes in the peptide and MHC molecules have been extensively examined for how they alter T cell activation, but many fewer studies have examined the TCR. Structural studies of how TCR differences alter T cell specificity have focused on broad variation in the CDR3 loops. However, changes in the CD...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3467324/ https://ncbi.nlm.nih.gov/pubmed/22982754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2012.08.020 |
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