TCRβ repertoire of CD4(+) and CD8(+) T cells is distinct in richness, distribution, and CDR3 amino acid composition

The TCR repertoire serves as a reservoir of TCRs for recognizing all potential pathogens. Two major types of T cells, CD4(+) and CD8(+), that use the same genetic elements and process to generate a functional TCR differ in their recognition of peptide bound to MHC class II and I, respectively. Howev...

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Veröffentlicht in:J Leukoc Biol
Hauptverfasser: Li, Hoi Ming, Hiroi, Toyoko, Zhang, Yongqing, Shi, Alvin, Chen, Guobing, De, Supriyo, Metter, E. Jeffrey, Wood, William H., Sharov, Alexei, Milner, Joshua D., Becker, Kevin G., Zhan, Ming, Weng, Nan-ping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Leukocyte Biology 2016
Schlagworte:
Systems Biology & Immunogenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338248/
https://ncbi.nlm.nih.gov/pubmed/26394815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.6A0215-071RR
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