Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile

BACKGROUND: CD4 T lymphocyte activation requires T cell receptor (TCR) engagement by peptide/MHC (major histocompatibility complex) (pMHC). The TCR complementarity-determining region 3 (CDR3) contains variable α and β loops critical for pMHC recognition. During any immune response, tuning of TCR usa...

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Autori principali: Reynolds, Catherine, Chong, Deborah, Raynsford, Eleanor, Quigley, Kathryn, Kelly, Deborah, Llewellyn-Hughes, Julia, Altmann, Daniel, Boyton, Rosemary
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4046507/
https://ncbi.nlm.nih.gov/pubmed/24886643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-12-32
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