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Class II-restricted T cell receptor engineered in vitro for higher affinity retains peptide specificity and function
The T cell receptor (TCR) αβ heterodimer determines the peptide and MHC specificity of a T cell. It has been proposed that in vivo selection processes maintain low TCR affinities because T cells with higher-affinity TCRs would (i) have reduced functional capacity or (ii) cross-react with self-peptid...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1323173/ https://ncbi.nlm.nih.gov/pubmed/16365315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507554102 |
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