EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers

The involvement of the MET oncogene in de novo and acquired resistance of non-small cell lung cancers (NSCLC) to tyrosine kinase inhibitors (TKIs) has been reported, but the precise mechanism by which MET overexpression contributes to TKI-resistant NSCLC remains unclear. MicroRNAs (miRNAs) negativel...

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Main Authors: Garofalo, Michela, Romano, Giulia, Di Leva, Gianpiero, Nuovo, Gerard, Jeon, Young-Jun, Ngankeu, Apollinaire, Sun, Jin, Lovat, Francesca, Alder, Hansjuerg, Condorelli, Gerolama, Engelman, Jeffrey A, Ono, Mayumi, Rho, Jin Kyung, Cascione, Luciano, Volinia, Stefano, Nephew, Kenneth P., Croce, Carlo M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467100/
https://ncbi.nlm.nih.gov/pubmed/22157681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2577
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