A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

Presenilins 1 and 2 (PS1 and PS2) are the catalytic subunits of the γ-secretase complex, and genes encoding mutant PS1 and PS2 variants cause familial forms of Alzheimer's disease. Lee et al. (2010) recently reported that loss of PS1 activity lead to impairments in autophagosomal function as a...

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Bibliografiske detaljer
Main Authors: Zhang, Xulun, Garbett, Krassimira, Veeraraghavalu, Karthikeyan, Wilburn, Brian, Gilmore, Reid, Mirnics, Karoly, Sisodia, Sangram S.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467018/
https://ncbi.nlm.nih.gov/pubmed/22723704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0556-12.2012
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