Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice

BACKGROUND: Familial Alzheimer's disease-linked variants of presenilin (PSEN1 and PSEN2) contribute to the pathophysiology of disease by both gain-of-function and loss-of-function mechanisms. Deletions of PSEN1 and PSEN2 in the mouse forebrain result in a strong and progressive neurodegenerativ...

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Bibliografiske detaljer
Main Authors: Mirnics, Károly, Norstrom, Eric M, Garbett, Krassimira, Choi, Se Hoon, Zhang, Xiaoqiong, Ebert, Philip, Sisodia, Sangram S
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569036/
https://ncbi.nlm.nih.gov/pubmed/18834536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-3-14
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