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Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons

The prevalence of obesity in older people is the leading cause of metabolic syndromes. Central neurons serving as homeostatic sensors for bodyweight control include hypothalamic neurons that express pro-opiomelanocortin (POMC) or neuropeptide-Y (NPY) and agouti-related protein (AgRP). Here we report...

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Библиографические подробности
Главные авторы: Yang, Shi-Bing, Tien, An-Chi, Boddupalli, Gayatri, Xu, Allison W., Jan, Yuh Nung, Jan, Lily Yeh
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467009/
https://ncbi.nlm.nih.gov/pubmed/22884327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.03.043
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