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Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
The prevalence of obesity in older people is the leading cause of metabolic syndromes. Central neurons serving as homeostatic sensors for bodyweight control include hypothalamic neurons that express pro-opiomelanocortin (POMC) or neuropeptide-Y (NPY) and agouti-related protein (AgRP). Here we report...
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| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3467009/ https://ncbi.nlm.nih.gov/pubmed/22884327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.03.043 |
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