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Estrogen directly down-regulates the bone-resorbing activity of mature osteoclasts through nuclear estrogen receptor α

The decrease in estrogen level that follows the onset ofmenopause causes rapid bone loss, resulting in osteoporosis.However, the mechanism remains unclear, especially concerningthe regulation of bone-resorbing osteoclasts. Here we analyzedthe function of estrogen and its receptor in matureosteoclast...

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Main Authors: Mano, Hiroshi, Hakeda, Yoshiyuki, Kumegawa, Masayoshi
Formato: Artigo
Idioma:Inglês
Publicado: Kluwer Academic Publishers 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466614/
https://ncbi.nlm.nih.gov/pubmed/19003277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1008188120766
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