Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

Estrogen deficiency causes bone loss, which can be prevented by estrogen replacement therapy. Using a recently developed technique for isolation of highly purified mammalian osteoclasts, we showed that 17 β-estradiol (E(2)) was able to directly inhibit osteoclastic bone resorption. At concentrations...

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Hauptverfasser: Kameda, Takashi, Mano, Hiroshi, Yuasa, Tatsuhisa, Mori, Yoshihisa, Miyazawa, Koshi, Shiokawa, Miho, Nakamaru, Yukiya, Hiroi, Emi, Hiura, Kenji, Kameda, Akira, Yang, Na N., Hakeda, Yoshiyuki, Kumegawa, Masayoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1997
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199029/
https://ncbi.nlm.nih.gov/pubmed/9254647
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