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Oncogenic transcription factors as master regulators of chromatin topology: A new role for ERG in prostate cancer

The three-dimensional (3D) conformation of the genome is known to be structured and to affect gene transcription, but how chromatin conformation changes in diseases such as cancer is poorly understood. Similarly, oncogenic transcription factors bind to thousands of sites in the genome without a clea...

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Bibliografiske detaljer
Main Authors: Elemento, Olivier, Rubin, Mark A., Rickman, David S.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466547/
https://ncbi.nlm.nih.gov/pubmed/22918253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21401
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