Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells

The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it is unclear whether the maintenance of polyfunctionality is related to particular cellular phenotypic characteristics. To determine whethe...

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Bibliographic Details
Main Authors: Riou, Catherine, Treurnicht, Florette, Abrahams, Melissa-Rose, Mlisana, Koleka, Liu, Michael K.P., Goonetilleke, Nilu, Koup, Richard, Roederer, Mario, Karim, Salim Abdool, de Bruyn, Guy, Williamson, Carolyn, Gray, Clive M., Burgers, Wendy A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466366/
https://ncbi.nlm.nih.gov/pubmed/22966086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201488
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