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Increased memory differentiation is associated with decreased polyfunctionality for HIV but not for CMV-specific CD8+ T cells

The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it is unclear whether the maintenance of polyfunctionality is related to particular cellular phenotypic characteristics. To determine whethe...

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Detalhes bibliográficos
Main Authors: Riou, Catherine, Treurnicht, Florette, Abrahams, Melissa-Rose, Mlisana, Koleka, Liu, Michael K.P., Goonetilleke, Nilu, Koup, Richard, Roederer, Mario, Karim, Salim Abdool, de Bruyn, Guy, Williamson, Carolyn, Gray, Clive M., Burgers, Wendy A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466366/
https://ncbi.nlm.nih.gov/pubmed/22966086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201488
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