Novel Agents Targeting the IGF-1R/PI3K Pathway Impair Cell Proliferation and Survival in Subsets of Medulloblastoma and Neuroblastoma

The receptor tyrosine kinase (RTK)/phosphoinositide 3-kinase (PI3K) pathway is fundamental for cancer cell proliferation and is known to be frequently altered and activated in neoplasia, including embryonal tumors. Based on the high frequency of alterations, targeting components of the PI3K signalin...

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Autori principali: Wojtalla, Anna, Salm, Fabiana, Christiansen, Ditte G., Cremona, Tiziana, Cwiek, Paulina, Shalaby, Tarek, Gross, Nicole, Grotzer, Michael A., Arcaro, Alexandre
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466180/
https://ncbi.nlm.nih.gov/pubmed/23056595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047109
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