(31)P and (1)H MRS of DB-1 Melanoma Xenografts: Lonidamine Selectively Decreases Tumor Intracellular pH and Energy Status and Sensitizes Tumors to Melphalan

In vivo (31)P MRS demonstrates that human melanoma xenografts in immunosuppressed mice treated with lonidamine (LND, 100 mg/kg, i.p.) exhibit a decrease in intracellular pH (pHi) from 6.90 ± 0.05 to 6.33 ± 0.10 (p < 0.001), a slight decrease in extracellular pH (pHe) from 7.00 ± 0.04 to 6.80 ± 0....

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Main Authors: Nath, Kavindra, Nelson, David S., Ho, Andrew, Lee, Seung-Cheol, Darpolor, Moses M., Pickup, Stephen, Zhou, Rong, Heitjan, Daniel F., Leeper, Dennis B., Glickson, Jerry D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465621/
https://ncbi.nlm.nih.gov/pubmed/22745015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.2824
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