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(31)P and (1)H MRS of DB-1 Melanoma Xenografts: Lonidamine Selectively Decreases Tumor Intracellular pH and Energy Status and Sensitizes Tumors to Melphalan

In vivo (31)P MRS demonstrates that human melanoma xenografts in immunosuppressed mice treated with lonidamine (LND, 100 mg/kg, i.p.) exhibit a decrease in intracellular pH (pHi) from 6.90 ± 0.05 to 6.33 ± 0.10 (p < 0.001), a slight decrease in extracellular pH (pHe) from 7.00 ± 0.04 to 6.80 ± 0....

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Autors principals: Nath, Kavindra, Nelson, David S., Ho, Andrew, Lee, Seung-Cheol, Darpolor, Moses M., Pickup, Stephen, Zhou, Rong, Heitjan, Daniel F., Leeper, Dennis B., Glickson, Jerry D.
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465621/
https://ncbi.nlm.nih.gov/pubmed/22745015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nbm.2824
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