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Axonal degeneration in Alzheimer’s disease: When signaling abnormalities meet the axonal transport system

Alzheimer’s disease (AD) is characterized by progressive, age-dependent degeneration of neurons in the central nervous system. A large body of evidence indicates that neurons affected in AD follow a dying-back pattern of degeneration, where abnormalities in synaptic function and axonal connectivity...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kanaan, Nicholas M., Pigino, Gustavo F., Brady, Scott T., Lazarov, Orly, Binder, Lester I., Morfini, Gerardo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465504/
https://ncbi.nlm.nih.gov/pubmed/22721767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.06.003
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