Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing Familial Alzheimer's Disease-Linked Mutant Presenilin 1

Presenilins (PS) play a central role in γ-secretase-mediated processing of β-amyloid precursor protein (APP) and numerous type I transmembrane proteins. Expression of mutant PS1 variants causes familial forms of Alzheimer's disease (FAD). In cultured mammalian cells that express FAD-linked PS1...

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Autors principals: Lazarov, Orly, Morfini, Gerardo A., Pigino, Gustavo, Gadadhar, Archana, Chen, Xiangjun, Robinson, John, Ho, Hanson, Brady, Scott T., Sisodia, Sangram S.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801050/
https://ncbi.nlm.nih.gov/pubmed/17596450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4272-06.2007
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