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Cholesterol accumulation increases insulin granule size and impairs membrane trafficking
The formation of mature secretory granules is essential for proper storage and regulated release of hormones and neuropeptides. In pancreatic β-cells, cholesterol accumulation causes defects in insulin secretion and may participate in the pathogenesis of type 2 diabetes. Using a novel cholesterol an...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3465494/ https://ncbi.nlm.nih.gov/pubmed/22889194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2012.01407.x |
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