Late Endosomal Cholesterol Accumulation Leads to Impaired Intra-Endosomal Trafficking

BACKGROUND: Pathological accumulation of cholesterol in late endosomes is observed in lysosomal storage diseases such as Niemann-Pick type C. We here analyzed the effects of cholesterol accumulation in NPC cells, or as phenocopied by the drug U18666A, on late endosomes membrane organization and dyna...

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Bibliographic Details
Main Authors: Sobo, Komla, Le Blanc, Isabelle, Luyet, Pierre-Philippe, Fivaz, Marc, Ferguson, Charles, Parton, Robert G., Gruenberg, Jean, van der Goot, F. Gisou
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1952175/
https://ncbi.nlm.nih.gov/pubmed/17786222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000851
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