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Excess cholesterol inhibits glucose‐stimulated fusion pore dynamics in insulin exocytosis
Type 2 diabetes is caused by defects in both insulin sensitivity and insulin secretion. Glucose triggers insulin secretion by causing exocytosis of insulin granules from pancreatic β‐cells. High circulating cholesterol levels and a diminished capacity of serum to remove cholesterol from β‐cells are...
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| Publicado no: | J Cell Mol Med |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5661106/ https://ncbi.nlm.nih.gov/pubmed/28544529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13207 |
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