T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2(+) prostate and breast cancer cells

To produce genetically engineered T cells directed against prostate and breast cancer cells, we have cloned the T-cell receptor recognizing the HLA-A2–restricted T-cell recptor γ-chain alternate reading-frame protein (TARP)(4–13) epitope. TARP is a protein exclusively expressed in normal prostate ep...

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Hlavní autoři: Hillerdal, Victoria, Nilsson, Berith, Carlsson, Björn, Eriksson, Fredrik, Essand, Magnus
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465394/
https://ncbi.nlm.nih.gov/pubmed/23019373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209042109
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