Double-Detargeted Oncolytic Adenovirus Shows Replication Arrest in Liver Cells and Retains Neuroendocrine Cell Killing Ability

BACKGROUND: We have previously developed an oncolytic serotype 5 adenovirus (Ad5) with chromogranin-A (CgA) promoter-controlled E1A expression, Ad[CgA-E1A], with the intention to treat neuroendocrine tumors, including carcinoids. Since carcinoids tend to metastasize to the liver it is important to f...

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Detalhes bibliográficos
Main Authors: Leja, Justyna, Nilsson, Berith, Yu, Di, Gustafson, Elisabet, Åkerström, Göran, Öberg, Kjell, Giandomenico, Valeria, Essand, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2811733/
https://ncbi.nlm.nih.gov/pubmed/20111709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008916
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