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Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors

Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surfaces of tumor cells. Furthermore, infected cells overproduce adenovirus fiber proteins, whi...

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Detalhes bibliográficos
Main Authors: Yu, Di, Jin, Chuan, Leja, Justyna, Majdalani, Nadim, Nilsson, Berith, Eriksson, Fredrik, Essand, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233137/
https://ncbi.nlm.nih.gov/pubmed/21957304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05759-11
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