Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Recombinant adenovirus serotype 5 (Ad5) vectors represent one of the most efficient gene delivery vectors in life sciences. However, Ad5 is dependent on expression of the coxsackievirus-adenovirus-receptor (CAR) on the surface of target cell for efficient transduction, which limits it’s utility for...

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Detalhes bibliográficos
Main Authors: Yu, Di, Jin, Chuan, Ramachandran, Mohanraj, Xu, Jing, Nilsson, Berith, Korsgren, Olle, Le Blanc, Katarina, Uhrbom, Lene, Forsberg-Nilsson, Karin, Westermark, Bengt, Adamson, Rachel, Maitland, Norman, Fan, Xiaolong, Essand, Magnus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555985/
https://ncbi.nlm.nih.gov/pubmed/23372800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054952
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