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Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer
Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR transgene in T cells, which is achieved by delivering transgene using integrating gamma retrovirus (RV) or lentivirus (LV...
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| Pubblicato in: | EMBO Mol Med |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4931286/ https://ncbi.nlm.nih.gov/pubmed/27189167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505869 |
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