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Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer

Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR transgene in T cells, which is achieved by delivering transgene using integrating gamma retrovirus (RV) or lentivirus (LV...

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Bibliografske podrobnosti
izdano v:EMBO Mol Med
Main Authors: Jin, Chuan, Fotaki, Grammatiki, Ramachandran, Mohanraj, Nilsson, Berith, Essand, Magnus, Yu, Di
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931286/
https://ncbi.nlm.nih.gov/pubmed/27189167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505869
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