CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T regulatory (Treg) cell therapy has proved to be beneficial, but generation of stable CNS-targeting Tregs needs further develo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Fransson, Moa, Piras, Elena, Burman, Joachim, Nilsson, Berith, Essand, Magnus, Lu, BinFeng, Harris, Robert A, Magnusson, Peetra U, Brittebo, Eva, Loskog, Angelica SI
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2012
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403996/
https://ncbi.nlm.nih.gov/pubmed/22647574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-112
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