Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer

Abstract Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR transgene in T cells, which is achieved by delivering transgene using integrating gamma retrovirus (RV) or lenti...

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Main Authors: Chuan Jin, Grammatiki Fotaki, Mohanraj Ramachandran, Berith Nilsson, Magnus Essand, Di Yu
Format: Artigo
Jezik:Inglês
Izdano: Springer Nature 2016-05-01
Serija:EMBO Molecular Medicine
Teme:
CAR T cells
episomal cell engineering
non‐integrating lentivirus (NILV)
scaffold/matrix attachment region (S/MAR) element
self‐replicating DNA
Online dostop:https://doi.org/10.15252/emmm.201505869
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