Glucose-6-Phosphate Dehydrogenase and NADPH Redox Regulates Cardiac Myocyte L-Type Calcium Channel Activity and Myocardial Contractile Function

We recently demonstrated that a 17-ketosteroid, epiandrosterone, attenuates L-type Ca(2+) currents (I(Ca-L)) in cardiac myocytes and inhibits myocardial contractility. Because 17-ketosteroids are known to inhibit glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosp...

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Bibliographic Details
Main Authors: Rawat, Dhwajbahadur K., Hecker, Peter, Watanabe, Makino, Chettimada, Sukrutha, Levy, Richard J., Okada, Takao, Edwards, John G., Gupte, Sachin A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465299/
https://ncbi.nlm.nih.gov/pubmed/23071515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045365
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