Treatment with MOG-DNA vaccines induces CD4(+)CD25(+)FoxP3(+) regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

BACKGROUND: DNA vaccines represent promising therapeutic strategies in autoimmune disorders such as multiple sclerosis (MS). However, the precise mechanisms by which DNA vaccines induce immune regulation remain largely unknown. Here, we aimed to expand previous knowledge existing on the mechanisms o...

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Autori principali: Fissolo, Nicolás, Costa, Carme, Nurtdinov, Ramil N, Bustamante, Marta F, Llombart, Victor, Mansilla, María J, Espejo, Carmen, Montalban, Xavier, Comabella, Manuel
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464883/
https://ncbi.nlm.nih.gov/pubmed/22727044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-139
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