Treatment with MOG-DNA vaccines induces CD4(+)CD25(+)FoxP3(+) regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

BACKGROUND: DNA vaccines represent promising therapeutic strategies in autoimmune disorders such as multiple sclerosis (MS). However, the precise mechanisms by which DNA vaccines induce immune regulation remain largely unknown. Here, we aimed to expand previous knowledge existing on the mechanisms o...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Fissolo, Nicolás, Costa, Carme, Nurtdinov, Ramil N, Bustamante, Marta F, Llombart, Victor, Mansilla, María J, Espejo, Carmen, Montalban, Xavier, Comabella, Manuel
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464883/
https://ncbi.nlm.nih.gov/pubmed/22727044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-139
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki