Treatment with MOG-DNA vaccines induces CD4(+)CD25(+)FoxP3(+) regulatory T cells and up-regulates genes with neuroprotective functions in experimental autoimmune encephalomyelitis

BACKGROUND: DNA vaccines represent promising therapeutic strategies in autoimmune disorders such as multiple sclerosis (MS). However, the precise mechanisms by which DNA vaccines induce immune regulation remain largely unknown. Here, we aimed to expand previous knowledge existing on the mechanisms o...

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Autors principals: Fissolo, Nicolás, Costa, Carme, Nurtdinov, Ramil N, Bustamante, Marta F, Llombart, Victor, Mansilla, María J, Espejo, Carmen, Montalban, Xavier, Comabella, Manuel
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464883/
https://ncbi.nlm.nih.gov/pubmed/22727044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-139
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