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AAV Vectors Containing rDNA Homology Display Increased Chromosomal Integration and Transgene Persistence
Although recombinant adeno-associated viral (rAAV) vectors are promising tools for gene therapy of genetic disorders, they remain mostly episomal and hence are lost during cell replication. For this reason, rAAV vectors capable of chromosomal integration would be desirable. Ribosomal DNA (rDNA) repe...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3464636/ https://ncbi.nlm.nih.gov/pubmed/22990673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.157 |
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