AAV Vectors Containing rDNA Homology Display Increased Chromosomal Integration and Transgene Persistence

Although recombinant adeno-associated viral (rAAV) vectors are promising tools for gene therapy of genetic disorders, they remain mostly episomal and hence are lost during cell replication. For this reason, rAAV vectors capable of chromosomal integration would be desirable. Ribosomal DNA (rDNA) repe...

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Hlavní autoři: Wang, Zhongya, Lisowski, Leszek, Finegold, Milton J, Nakai, Hiroyuki, Kay, Mark A, Grompe, Markus
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464636/
https://ncbi.nlm.nih.gov/pubmed/22990673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.157
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