The Antibodies against the Computationally Designed Mimic of the Glycoprotein Hormone Receptor Transmembrane Domain Provide Insights into Receptor Activation and Suppress the Constitutively Activated Receptor Mutants

The exoloops of glycoprotein hormone receptors (GpHRs) transduce the signal generated by the ligand-ectodomain interactions to the transmembrane helices either through direct hormonal contact and/or by modulating the interdomain interactions between the hinge region (HinR) and the transmembrane doma...

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Autores principales: Majumdar, Ritankar, Railkar, Reema, Dighe, Rajan R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464559/
https://ncbi.nlm.nih.gov/pubmed/22904318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355032
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