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The Hinge Region of Human Thyroid-Stimulating Hormone (TSH) Receptor Operates as a Tunable Switch between Hormone Binding and Receptor Activation

The mechanism by which the hinge regions of glycoprotein hormone receptors couple hormone binding to activation of downstream effecters is not clearly understood. In the present study, agonistic (311.62) and antagonistic (311.87) monoclonal antibodies (MAbs) directed against the TSH receptor extrace...

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Hlavní autoři: Majumdar, Ritankar, Dighe, Rajan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391290/
https://ncbi.nlm.nih.gov/pubmed/22792265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040291
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