Attenuation of T Cell Receptor Signaling by Serine Phosphorylation-mediated Lysine 30 Ubiquitination of SLP-76 Protein

SLP-76 (SH2 domain-containing leukocyte protein of 76 kDa) is an adaptor protein that is essential for T cell development and T cell receptor (TCR) signaling activation. Previous studies have identified an important negative feedback regulation of SLP-76 by HPK1 (hematopoietic progenitor kinase 1; M...

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Bibliographic Details
Main Authors: Wang, Xiaohong, Li, Ju-Pi, Chiu, Li-Li, Lan, Joung-Liang, Chen, Der-Yuan, Boomer, Jonathan, Tan, Tse-Hua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464518/
https://ncbi.nlm.nih.gov/pubmed/22902619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371062
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