Down-regulation of B Cell Receptor Signaling by Hematopoietic Progenitor Kinase 1 (HPK1)-mediated Phosphorylation and Ubiquitination of Activated B Cell Linker Protein (BLNK)

Hematopoietic progenitor kinase 1 (HPK1) is a Ste20-like serine/threonine kinase that suppresses immune responses and autoimmunity. B cell receptor (BCR) signaling activates HPK1 by inducing BLNK/HPK1 interaction. Whether HPK1 can reciprocally regulate BLNK during BCR signaling is unknown. Here, we...

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Detalhes bibliográficos
Main Authors: Wang, Xiaohong, Li, Ju-Pi, Kuo, Hui-Kai, Chiu, Li-Li, Dement, Gregory A., Lan, Joung-Liang, Chen, Der-Yuan, Yang, Chia-Yu, Hu, Hongbo, Tan, Tse-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322877/
https://ncbi.nlm.nih.gov/pubmed/22334673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310946
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