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Phosphorylation of CARMA1 by HPK1 is critical for NF-κB activation in T cells
Activation of the NF-κB pathway in T cells is required for induction of an adaptive immune response. Hematopoietic progenitor kinase (HPK1) is an important proximal mediator of T-cell receptor (TCR)-induced NF-κB activation. Knock-down of HPK1 abrogates TCR-induced IKKβ and NF-κB activation, whereas...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732850/ https://ncbi.nlm.nih.gov/pubmed/19706536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900457106 |
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