Phosphorylation of CARMA1 by HPK1 is critical for NF-κB activation in T cells

Activation of the NF-κB pathway in T cells is required for induction of an adaptive immune response. Hematopoietic progenitor kinase (HPK1) is an important proximal mediator of T-cell receptor (TCR)-induced NF-κB activation. Knock-down of HPK1 abrogates TCR-induced IKKβ and NF-κB activation, whereas...

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Main Authors: Brenner, Dirk, Brechmann, Markus, Röhling, Simone, Tapernoux, Myriam, Mock, Thomas, Winter, Dominic, Lehmann, Wolf D., Kiefer, Friedemann, Thome, Margot, Krammer, Peter H., Arnold, Rüdiger
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732850/
https://ncbi.nlm.nih.gov/pubmed/19706536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900457106
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