Activation or suppression of NFκB by HPK1 determines sensitivity to activation-induced cell death

Restimulation of the T-cell receptor (TCR) in activated T cells induces CD95 (Fas/Apo-1)-mediated activation-induced cell death (AICD). The TCR-proximal mechanisms leading to AICD are elusive. Here we characterize hematopoietic progenitor kinase 1 (HPK1) as a differentially regulated TCR-proximal si...

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Detalhes bibliográficos
Main Authors: Brenner, Dirk, Golks, Alexander, Kiefer, Friedemann, Krammer, Peter H, Arnold, Rüdiger
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1356335/
https://ncbi.nlm.nih.gov/pubmed/16341093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600894
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