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The Protein Phosphatase 2A Regulatory Subunit B56γ Mediates Suppression of T Cell Receptor (TCR)-induced Nuclear Factor-κB (NF-κB) Activity

NF-κB is an important transcription factor in the immune system, and aberrant NF-κB activity contributes to malignant diseases and autoimmunity. In T cells, NF-κB is activated upon TCR stimulation, and signal transduction to NF-κB activation is triggered by a cascade of phosphorylation events. Howev...

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Détails bibliographiques
Auteurs principaux: Breuer, Rebecca, Becker, Michael S., Brechmann, Markus, Mock, Thomas, Arnold, Rüdiger, Krammer, Peter H.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031550/
https://ncbi.nlm.nih.gov/pubmed/24719332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533547
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