Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

Apert syndrome (AS) is characterized by craniosynostosis (premature fusion of cranial sutures) and severe syndactyly of the hands and feet. Two activating mutations, Ser-252 → Trp and Pro-253 → Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS. To elucidate...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ibrahimi, Omar A., Eliseenkova, Anna V., Plotnikov, Alexander N., Yu, Kai, Ornitz, David M., Mohammadi, Moosa
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11390973/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.121183798
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