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Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
Apert syndrome (AS) is characterized by craniosynostosis (premature fusion of cranial sutures) and severe syndactyly of the hands and feet. Two activating mutations, Ser-252 → Trp and Pro-253 → Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS. To elucidate...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC34643/ https://ncbi.nlm.nih.gov/pubmed/11390973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121183798 |
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