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Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

Apert syndrome (AS) is characterized by craniosynostosis (premature fusion of cranial sutures) and severe syndactyly of the hands and feet. Two activating mutations, Ser-252 → Trp and Pro-253 → Arg, in fibroblast growth factor receptor 2 (FGFR2) account for nearly all known cases of AS. To elucidate...

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Bibliografiske detaljer
Main Authors: Ibrahimi, Omar A., Eliseenkova, Anna V., Plotnikov, Alexander N., Yu, Kai, Ornitz, David M., Mohammadi, Moosa
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC34643/
https://ncbi.nlm.nih.gov/pubmed/11390973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.121183798
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