Δ-9,11 Modification of Glucocorticoids Dissociates Nuclear Factor-κB Inhibitory Efficacy from Glucocorticoid Response Element-Associated Side Effects

Glucocorticoids are standard of care for many inflammatory conditions, but chronic use is associated with a broad array of side effects. This has led to a search for dissociative glucocorticoids—drugs able to retain or improve efficacy associated with transrepression [nuclear factor-κB (NF-κB) inhib...

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Hlavní autoři: Baudy, Andreas R., Reeves, Erica K. M., Damsker, Jesse M., Heier, Christopher, Garvin, Lindsay M., Dillingham, Blythe C., McCall, John, Rayavarapu, Sree, Wang, Zuyi, Vandermeulen, Jack H., Sali, Arpana, Jahnke, Vanessa, Duguez, Stephanie, DuBois, Debra, Rose, Mary C., Nagaraju, Kanneboyina, Hoffman, Eric P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2012
Témata:
Cellular and Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464029/
https://ncbi.nlm.nih.gov/pubmed/22743576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.194340
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