Δ-9,11 Modification of Glucocorticoids Dissociates Nuclear Factor-κB Inhibitory Efficacy from Glucocorticoid Response Element-Associated Side Effects

Glucocorticoids are standard of care for many inflammatory conditions, but chronic use is associated with a broad array of side effects. This has led to a search for dissociative glucocorticoids—drugs able to retain or improve efficacy associated with transrepression [nuclear factor-κB (NF-κB) inhib...

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Autors principals: Baudy, Andreas R., Reeves, Erica K. M., Damsker, Jesse M., Heier, Christopher, Garvin, Lindsay M., Dillingham, Blythe C., McCall, John, Rayavarapu, Sree, Wang, Zuyi, Vandermeulen, Jack H., Sali, Arpana, Jahnke, Vanessa, Duguez, Stephanie, DuBois, Debra, Rose, Mary C., Nagaraju, Kanneboyina, Hoffman, Eric P.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2012
Matèries:
Cellular and Molecular
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464029/
https://ncbi.nlm.nih.gov/pubmed/22743576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.194340
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